Hemarthrosis alters mitochondrial dynamics in situ after traumatic injury
نویسندگان
چکیده
منابع مشابه
Mitochondrial dysfunction early after traumatic brain injury in immature rats.
Mitochondria play central roles in acute brain injury; however, little is known about mitochondrial function following traumatic brain injury (TBI) to the immature brain. We hypothesized that TBI would cause mitochondrial dysfunction early (<4 h) after injury. Immature rats underwent controlled cortical impact (CCI) or sham injury to the left cortex, and mitochondria were isolated from both hem...
متن کاملMonitoring of β-amyloid dynamics after human traumatic brain injury.
Epidemiological evidence links severe or repeated traumatic brain injury (TBI) to the development of Alzheimer's disease (AD). Accumulation of amyloid precursor protein (APP) occurs with high frequency after TBI, particularly in injured axons, and APP may be cleaved to amyloid-β (Aβ) peptides playing key pathophysiological roles in AD. We used cerebral microdialysis (MD) to test the hypothesis ...
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متن کاملMitochondrial DNA and traumatic brain injury
OBJECTIVE Traumatic brain injury (TBI) is a multifactorial pathology with great interindividual variability in response to injury and outcome. Mitochondria contain their own DNA (mtDNA) with genomic variants that have different physiological and pathological characteristics, including susceptibility to neurodegeneration. Given the central role of mitochondria in the pathophysiology of neurologi...
متن کاملCoagulopathy after Traumatic Brain Injury
Copyright: © 2012 Alexiou GA. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Traumatic brain injury (TBI) is a major public health problem, leading to a considerable number of deaths and disability mainly amo...
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ژورنال
عنوان ژورنال: Osteoarthritis and Cartilage
سال: 2019
ISSN: 1063-4584
DOI: 10.1016/j.joca.2019.02.308